Vascular Risks, Aging, and Late-Onset Dementia: Overlapping Etiologies Point to 'Scavenger Receptor'-Mediated Therapeutics

Early changes in systemic vascular stiffness and endothelial function can contribute to altered cerebrovascular hemodynamics impaired cognitive function; additionally, these point potential targets for prevention treatment strategies people with mild impairment. Although the pathogenic mechanisms underlying are heterogeneous complex, one common feature is development of cerebral blood flow (CBF) dysregulation, resulting chronic hypoperfusion (CCH) subsequently an insufficient supply brain. However, incorporation drugs, or other bioactive molecules, into specifically a "high density lipoprotein-like" ("HDL-like") lipid nanocarrier result production multitasking "combination therapeutic" – capable targeting cell-surface scavenger receptors (mainly SR-BI). Such behavior this proposed (biomimetic-nanocarrier) therapeutic vehicle facilitate nanocarrier's enhanced endocytosis various target cells which, turn, increases likelihood that provides some efficacy at different stages dementia.